Feedback inhibition shapes emergent computational properties of cortical microcircuit motifs

Z. Jonke, R. Legenstein, S. Habenschuss, and W. Maass

Abstract:

Cortical microcircuits are very complex networks, but they are composed of a relatively small number of stereotypical motifs. Hence one strategy for throwing light on the computational function of cortical microcircuits it to analyze emergent computational properties of these stereotypical microcircuit motifs. We are addressing here the question how spike-timing dependent plasticity (STDP) shapes the computational properties of one motif that has frequently been studied experimentally: interconnected populations of pyramidal cells and parvalbumin-positive inhibitory cells in layer 2/3. Experimental studies suggest that these inhibitory neurons exert some form of divisive inhibition on the pyramidal cells. We show that this data-based form of feedback inhibition, which is softer than that of winner-take-all models that are commonly considered in theoretical analyses, contributes to the emergence of an important computational function through STDP: The capability to disentangle superimposed firing patterns in upstream networks, and to represent their information content through a sparse assembly code.

Reference: Z. Jonke, R. Legenstein, S. Habenschuss, and W. Maass. Feedback inhibition shapes emergent computational properties of cortical microcircuit motifs. Journal of Neuroscience, 37(35):8511-8523, 2017.